What is Fibromyalgia?

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain, accompanied by fatigue, sleep disturbances, memory problems, and mood issues. Patients often experience symptoms such as “fibro fog” — difficulties with concentration and memory — as well as headaches, irritable bowel syndrome, and increased sensitivity to touch or temperature (Mayo Clinic, 2023). The exact cause is unknown, but research suggests it involves abnormal processing of pain signals in the central nervous system. Physical trauma, infections, or emotional stressors may trigger or worsen the condition.

How Is Fibromyalgia Treated?

Diagnosis is clinical and based on symptom patterns since no definitive laboratory test exists. Treatment focuses on symptom management through a multidisciplinary approach:

Medications

Such as pain relievers, antidepressants, and anti-seizure drugs, which help reduce pain and improve sleep quality (Goldenberg et al., 2016).

Physical therapy

Tailored exercise programs to improve strength, flexibility, and stamina.

Cognitive behavioral therapy (CBT)

To help cope with symptoms and improve quality of life.

Lifestyle modifications

Stress reduction, good sleep hygiene, and balanced activity-rest cycles.

Ketamine and Fibromyalgia

In cases where conventional treatments fail, ketamine infusion therapy has been explored as an option. Ketamine acts as an NMDA receptor antagonist, disrupting the pathways involved in central sensitization and potentially reducing chronic pain symptoms. Clinical studies indicate ketamine infusions may provide short-term relief of fibromyalgia pain. Due to potential side effects, ketamine administration is done in controlled medical settings.