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Neuropathic pain is a complex, chronic pain condition resulting from damage or dysfunction in the nervous system, either peripheral nerves or the central nervous system . Neuropathic pain originates from abnormal nerve signaling and can cause burning, shooting, or electric shock-like sensations. Common causes include diabetes, shingles, multiple sclerosis, spinal cord injury, and nerve compression. Patients may also experience tingling, numbness, and hypersensitivity to stimuli that are normally not painful.
Neuropathic pain is often difficult to treat and typically requires a multidisciplinary intervcention:
First-line drugs include anticonvulsants, antidepressants, and topical agents like lidocaine patches.
Such as physical therapy, cognitive-behavioral therapy, and transcutaneous electrical nerve stimulation (TENS).
Nerve blocks or spinal cord stimulation may be considered for refractory cases.
Ketamine, an NMDA receptor antagonist, has shown promise in treating neuropathic pain by blocking excitatory glutamate signaling involved in central sensitization (Noppers et al., 2011). Ketamine infusions can reduce pain intensity in patients who do not respond to conventional treatments (Sigtermans et al., 2009). However, benefits may be temporary, and ketamine use requires close monitoring due to possible side effects.
Jacobs Pain Centre, 8920 Woodbine Ave, Ste. 102, Markham, ON L3R 9W9
Since 2002, Jacob’s Pain Centre has provided effective, comprehensive pain management through a multidisciplinary approach. We combine evidence-based treatments with supportive care to deliver accurate diagnoses and personalized pain management plans.
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